Higher Scientific Officer - Assay development and compound profiling

Under the leadership of Dr Rob van Montfort, we are seeking to appoint a highly motivated assay scientist keen to apply small molecule screening expertise to help progress our cancer drug discovery projects from assay development and hit finding to candidate selection. The successful candidate will develop and execute plate-based biochemical and/or cellular screening assays to support the identification and characterisation of small-molecule inhibitors against novel cancer targets using a variety of detection technologies.

Key Requirements

The successful candidate will be embedded in the Hit Discovery and Structural Design Team but work with multidisciplinary project teams.

Key requirements for the role are significant and broad all-round laboratory experience in the characterisation of small molecule binding to proteins and the investigation of protein function and activity applied to drug discovery. A good understanding of enzymology would be beneficial, as would prior use of automation equipment for liquid and compound handling used in compound profiling

Department/Directorate Information

The CCDD within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 150 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The CCDD’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the necessary scientific disciplines are in place to make this possible, including medicinal chemistry, cancer biology, structural biology, assay science, drug metabolism and clinical expertise.

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr Rob Van Montfort or Dr Caroline Ewens for further information by emailing [email protected] or [email protected]

This job description is a reflection of the current position and is subject to review and alteration in detail and emphasis in the light of future changes or development. Please DO NOT send your application to Dr Rob Van Montfort or Caroline Ewens, but apply via the e-recruitment system on our website www.icr.ac.uk.

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.