Postdoctoral Training Fellow: ADP-ribosylation in Wnt/β-catenin signalling and telomere maintenance

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Location:

Chelsea

Department:

Structural Biology of Cell Signalling

Salary Details:

Salary Range: £45,600 - £51,450 per annum

Contract:

Fixed term

Contract Length:

Not Specified

Advertising End Date:

29 Jun 2025

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Postdoctoral Training Fellow: ADP-ribosylation in Wnt/β-catenin signalling and telomere maintenance

Key Information

Salary: Dependent on relevant Postdoctoral experience.

This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here.

Duration of Contract: Fixed Term for 3 years

Hours per week: 35 hours per week (Full Time)

Location: Chelsea

Closing Date: 29 June 2025

Job Details

The full title of the role is Postdoctoral Training Fellow: Biochemistry and cell biology of ADP-ribosylation in Wnt/β-catenin signalling and telomere maintenance.

Under the guidance of Professor Sebastian Guettler, we are seeking to recruit a Postdoctoral Training Fellow to investigate the molecular mechanisms of tankyrase regulation and function, building on recent insights from structural and genetic studies.

The post would be particularly suitable for a candidate seeking to apply cellular biochemistry, mammalian genetics(CRISPR) and light microscopy (including live-cell imaging) to investigate the function and mechanism of tankyrase in various cellular roles, particularly Wnt/beta-catenin signalling and telomere maintenance. The position will offer a stimulating balance of independence and collaboration.

About you

The successful candidate must have:

- a PhD in a biological science
- solid experience in recombinant DNA techniques and mammalian genetics (CRISPR)
- solid experience in mammalian cell biology and cellular biochemistry
- evidence of contributing to research publications

Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment.

The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years.

For general information on Postdocs at The ICR, more information can be found here.

Department/Directorate Information

Work in the Structural Biology of Cell Signalling Team, led by Professor Sebastian Guettler, in the ICR Divisions of Structural Biology and Cell and Molecular Biology, centres on the molecular mechanisms of Wnt/beta-catenin signalling and telomere maintenance, both of which play key roles in stem cells and a wide range of cancers. A core interest of the team is to understand how ADP-ribosylation, a complex and extremely versatile post-translational modification, controls both these systems, and how ADP-ribosyltransferases are themselves regulated.

What we offer

A dynamic and supportive research environment
Access to state-of-the-art facilities and professional development opportunities
Collaboration with leading researchers in the field
Competitive salary and pension

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact s[email protected].

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.

Don't let a checklist of qualifications hold you back – if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.

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