Postdoctoral Training Fellow - Biochemistry and Cell Biology of Wnt - β-catenin signalling

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Location:

Chelsea

Position:

Structural Biology of Cell Signalling

Salary Details:

45,600 per annum

Contract:

Fixed term

Contract Length:

Not Specified

Advertising End Date:

30 Nov 2025

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Postdoctoral Training Fellow - Biochemistry and Cell Biology of Wnt - β-catenin signalling

Key Information

Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performance review.

This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here.

Duration of Contract: Fixed Term for 3 years initially

Hours per week: 35 hours per week (Full Time)

Location: Chelsea

Closing Date: 30 November 2025

Job Details

Under the guidance of Professor Sebastian Guettler, we are seeking to recruit a Postdoctoral Training Fellow to to investigate the molecular mechanisms of Wnt/β-catenin signalling, using a combination of mammalian genetics, cell biology, proteomics and biochemistry. The successful candidate will apply mammalian genetics (CRISPR), cellular biochemistry, proteomics and light microscopy (including live-cell imaging) to investigate the mechanisms of Wnt/β-catenin signalling in normal physiology and cancer. The particular focus of the project will be on studying the molecular mechanisms underlying the activities and regulation of the β-catenin destruction complex and its dysregulation in APC-mutant cancers, particularly colorectal cancer. The position will offer a stimulating balance of independence and collaboration.

The candidate will join a multidisciplinary, collaborative and international team with a core expertise in biochemistry, structural biology (electron microscopy, X-ray crystallography), biophysics and genetics, and established collaborations in chemistry and proteomics.

About you

The successful candidate must have a PhD in a biological science or any other area relevant to the proposed research, and experience in contemporary molecular biology, mammalian genetics, cell biology and biochemistry.

Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment.

The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years.

For general information on Postdocs at The ICR, more information can be found here.

Department/Directorate Information

Work in the Structural Biology of Cell Signalling Team, led by Professor Sebastian Guettler, in the ICR Divisions of Structural Biology and Cell and Molecular Biology, centres on the molecular mechanisms of Wnt/β-catenin signalling and telomere maintenance, both of which play key roles in stem cells and a wide range of cancers. A long-standing interest of the team is to understand how ADP-ribosylation, a complex and extremely versatile post-translational modification, controls both these systems, and how the ADP-ribosyltransferase tankyrase is regulated.

What we offer

A dynamic and supportive research environment
Access to state-of-the-art facilities and professional development opportunities
Collaboration with leading researchers in the field
Competitive salary and pension

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Sebastian Guettler via e-mail on [email protected].

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.

Don't let a checklist of qualifications hold you back – if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.

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