Location
Sutton (Greater London)
Department
Molecular Pathology
Advertising Salary
Salary Range: £32,000 - £44,400 per annum
Vacancy Type
Fixed term
External Advertising End Date
29 May 2022

Key Information

Salary: Commencement on the salary range is subject to comparable skills and experience. Future progression is based on annual performance review.

Duration of Contract: Fixed Term for 2 years

Hours per week: 35 hours per week (Full Time)

Closing Date: 29th May 2022

 

Job Details

 

Research Lead: Prof Louis Chesler & Dr Alejandra Bruna

Summary of Role

We have an opportunity for a Higher Scientific Officer (HSO) to oversee and provide technical support a collaborative environment that aims to further our understanding on the mechanisms underlying solid peadiatric tumours adaptation and evolution to treatment and in relapse. The post-holder will be strategically supported by the fruitful and complementary alliance between PCE lab and Professor Louis Chesler’s lab (director of the Paediatric Oncology Experimental Medicine and head of the Paediatric Tumour Biology lab), which will provide an excellent combination of expertise, tools, knowledge, and guidance. The post holder will be involved in preclinical work involving patient derived tumour models from difficult-to-treat paediatric cancers ex vivo and in vivo. The candidate will also collaborate with other members of the lab to generate high-dimensional datasets (CyTOF, bulk DNA and RNA-seq and scRNA-seq/lineage tracing). You will closely interact and support other researchers within the group as well as internal and external collaborative efforts, including those within ICR state-of-the-art core facilities, assisting and overseeing a highly collaborative framework in paediatric preclinical modelling.

You are expected to participate in the day-to-day running of the laboratory, including ordering supplies, maintaining inventories. 

Key Requirements

Applicants must have a degree in Biochemistry, Molecular Biology or Cell Biology and in-depth technical laboratory experience in data management, molecular biology and cell biology including cell lines. Experience on genomics, especially library preparation, together with knowledge and ability to perform standard laboratory techniques are desirable. Knowledge of cancer biology, 2-D and 3-D cell culture and cell viability assay methodologies, and familiarity with contemporary approaches to the generation of genetic modifications, such as the use of CRISPR, would also be advantageous.

Department/Directorate Information:

The Preclinical Modelling of Paediatric Cancer Evolution team (PCE team) led by Dr. Alejandra Bruna is interested in studying the molecular mechanisms underlying paediatric cancer evolutionary processes leading to therapy resistance and relapse. 

The PCE lab is part of the Centre for Paediatric Oncology Experimental Medicine and the Centre for Evolution and Cancer and of the Division of Molecular Pathology. It is located at the newly built, multidisciplinary Centre for Cancer Drug Discovery in Sutton, London. 

We encourage all applicants to access the job pack attached for more detailed information regarding this role. 

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

 

We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.


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