Location
Sutton (Greater London)
Department
Molecular Pathology
Advertising Salary
Salary Range: £32,000 - £44,400 per annum
Vacancy Type
Fixed term
External Advertising End Date
21 Aug 2022

Key Information

Salary: Commencement on the salary range is subject to comparable skills and experience. Future progression is based on annual performance review.

This role is eligible for ICR Sponsorship.  Support will be provided for costs associated with Visa application and health surcharge.

Duration of Contract: Fixed Term for 3 years

Hours per week: 35 hours per week (Full Time)

Closing Date:  21 August 2022

Job Details

Research LeadProfessor Trevor Graham

Summary of Role

We are seeking a Higher Scientific Officer to coordinate the collection, processing and storage of patient tissue, and to provide laboratory-based technical and scientific support to the Genomics and Evolutionary Dynamics team. The position occupies a central role within our team, and as such the post holder will be required to liaise closely with wet-lab, clinical and computational staff. 

The Genomics and Evolutionary Dynamics team is highly diverse and interdisciplinary group of about 15 people, consisting of clinicians, biologists, mathematicians and computational scientists. We combine (epi)genomic, transcriptomic and histological data with bioinformatics and mathematical modelling to reconstruct the evolutionary history of cancers and predict the direction that future evolution will take. Our hope is to translate this knowledge for patient benefit, by deriving evolutionary biomarkers for prognosis and treatment response. We focus predominantly on colorectal cancer.

We are based at the ICR Sutton site within the Centre for Evolution and Cancer, located in the outstanding facilities of the newly opened Centre for Cancer Drug Discovery building. The team is highly experienced in multi-omic data generation and integration, and using this in-house data together with large publicly available datasets, we apply the principles of evolutionary biology and ecology to understand the natural history of cancer. Pertinent to this role, we are equipped with cutting-edge single cell sequencing technologies such as the cellenONE (Cellenion) and the Chromium system (10X Genomics), with further access to an on-site Illumina Novaseq in the sequencing core facility. Furthermore the team has access to a CODEX (Akoya Bioscience) for highly multiplexed spatial analysis.

Key Requirements

This role would suit an experienced laboratory researcher with a strong interest in cancer evolution and genetics, excellent organisational skills and the ability to work independently. The successful candidate would be part of a supportive and dynamic team conducting exciting and translational research into tumour evolution.


The successful candidate must have a PhD in a relevant subject (e.g. biological sciences) and must have demonstrable knowledge and interest in cancer evolution, genetics and epigenetics.

We ask that all applicants have experience of cancer research with patient samples, and an appropriate publication record for career stage. Furthermore, the role requires several years post-graduate experience in a research laboratory and practical experience in next generation sequencing techniques (such as whole genome sequencing or RNA sequencing) and in vitro models. Training in histology, microscopy or biobanking would be an advantage.

Department/Directorate Information

The Centre for Evolution and Cancer (CEC), within the Division of MolecularPathology, is a multidisciplinary centre, comprising around 40 staff dedicatedto understanding cancer evolution and leveraging this knowledge fortranslational benefit. Our interests span early detection through to treatmentof metastatic disease. The CEC brings together expertise in evolutionarytheory, computational biology and bioinformatics together with cutting-edgeresearch ability in cell and molecular biology to provide a stimulating andcreative interdisciplinary environment where new approaches to tackling cancercan thrive

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Trevor Graham via email on [email protected] 

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

 

We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.

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