LocationLocation:
Sutton (Greater London)
DepartmentDepartment:
Cancer Therapeutics
Salary Details:Salary Details:
Salary Range: £40,107 - £46,724 per annum
Contract:Contract:
Fixed term
Contract Length:Contract Length:
3 years
External Advertising End Date
11 Dec 2022

Key Information

Starting Salary: Future progression is based on annual performance review. If the candidate has not yet been awarded their PhD, the starting salary will be at £34,344 until the successful completion of their viva  

This role is eligible for ICR Sponsorship.  Support will be provided for costs associated with Visa application and health surcharge. If you are considering relocating to the UK, further information can be found here
 
 
Hours per week: 35 hours per week (Full Time)
 

Job Details

This role will be under the leadership of Professor Terence Rabbitt  We are seeking to appoint an highly motivated Post Doctoral Training Fellow. This project is a part of the CR-UK-NCI Grand Challenge Next Generation T cell therapies for childhood cancers (NexTGen).

This project is a part of the CR-UK-NCI Grand Challenge Next Generation T cell therapies for childhood cancers (NexTGen).

This project aims to develop intracellular antibodies to target cancer-specific chromosomal translocation fusion proteins, and development strategies to deliver these into cancer cells with tumours in vivo from cellular vehicles, specifically CAR-T cells.

Key Requirements

You should possess a PhD in molecular biology and have  experience in working with recombinant proteins, in particular phage antibodies. You must also have experience with protein engineering and cloning as well as tissue culture, transfection and lentivirus/retrovirus and biophysical methods for assaying protein interaction in cells.

The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up  to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years

 

Division Information:

Professor Terry Rabbitts’ research is focussed on new strategies using intracellular antibodies and derivates for therapy aimed at hard-to-drug chromosomal translocation gene products, such as tumour-specific chromosomal translocation fusion proteins. We are developing technologies using intracellular antibodies with warheads that influence cellular pathways to interfere with tumour viability together with methods to allow systemic delivery of these engineered intracellular antibodies.

The work is funded as part of CRUK-NCI-funded Grand Challenge programme NexTGen (Next Generation T cells for Childhood Cancer) aims to make fusion protein-specific intracellular antibodies to bind to EWS-FLI1 and related proteins. This will be delivered to tumours in vivo by hijacking tumour targeting CAR-T cells. The work will involve new methods for specific intracellular antibodies and delivery protocols utilising CAR-T cells and their recognition of tumour surfaces to mediate transfer of the intracellular antibodies.

We encourage all applicants to access the job pack attached for more detailed information regarding this role. You may contact Prof. Terry Rabbitts for further information by emailing [email protected] 

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

 

We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.


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