LocationLocation:
Sutton (Greater London)
DepartmentDepartment:
Hit Discovery & Structural Design
Salary Details:Salary Details:
£37,050 - £45,732
Contract:Contract:
Fixed term
External Advertising End Date
25 Feb 2024

Key Information

Salary: Commencement on the salary range is subject to comparable skills and experience. Future progression is based on annual performance review. 
This role is eligible for ICR Sponsorship.  Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here
 
Duration of ContractFixed Term for 2 Years
Hours per week: 35 hours per week (Full Time)
Closing Date: 25th February 2024

Job Details

A Higher Scientific Officer (HSO) position is available in Dr Rob van Montfort’s Hit Discovery and Structural Design Team within the CCDD. The team uses biochemical and biophysical assays to perform small-molecule high-throughput screening and fragment-based hit discovery, coupled with X-ray crystallography to enable structure-based drug design. These methodologies are underpinned by state-of-the art protein expression, purification and biophysical characterisation capabilities, allowing for the generation of large quantities of high-quality protein targets

Key Requirements

The successful candidate will be carrying out protein expression and purification as part of the CCDD’s research programmes and will be responsible for establishing biophysical assays such as Surface Plasmon Resonance (SPR), Thermal Shift Assay (TSA) and ligand-observed NMR (LO-NMR) to characterise these protein targets and their protein-protein and protein-ligand interactions. The HSO will be an integral member of multidisciplinary project teams within the CCDD at the ICR Sutton site, and will interact closely with biologists, computational chemists, medicinal chemists, assay scientists and structural biologists.

Applicants should have at least a BSc in a biochemistry or related biological subject, and ideally an MSc or PhD. Experience and demonstrable skills in molecular biology, protein expression in E. coli and protein purification are essential. Demonstrable practical experience of biophysical techniques (SPR, TSA and/or LO-NMR) is desirable.  Experience in protein expression in insect and/or mammalian cells is also highly desirable.

Department/Directorate Information

The Centre for Cancer Drug Discovery (CCDD), within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The CCDD’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the scientific disciplines are in place to make this possible, including medicinal chemistry, biology, structural biology, assay scientists, drug metabolism and clinical specialists. This is an exciting and fast-moving research setup and offers the opportunity to work within a multi-disciplinary environment using state-of-the-art techniques and equipment.

 We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr van Montfort [email protected] or Dr Le Bihan [email protected]

About The Institute of Cancer Research

Why work for us?

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.

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