LocationLocation:
Sutton (Greater London)
DepartmentDepartment:
Cancer Therapeutics
Salary Details:Salary Details:
£37,050 - £39,000
Contract:Contract:
Fixed term
External Advertising End Date
04 Mar 2024

Key Information

Salary: £37,050 to £39,000. Commencement on the salary range is subject to comparable skills and experience. Future progression is based on annual performance review.
Duration of ContractFixed Term for 2 years (with possibility of extension)
Hours per week: 35 hours per week (Full Time)
Closing Date4th March 2024
 
This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here.

Job Details

Under the leadership of Ling Li, we are seeking to appoint two Higher Scientific Officers to join the Tumour Microenvironment and Pharmacology team within the CCDD. The team combines strong scientific interest in understanding tumour microenvironment (TME) dynamics and targeting TME for novel therapeutic approaches with our long-standing expertise in tumour model development and pharmacological investigation. The research project is exploring ways to modulate MHC-I antigen presentation in order to re-engage the immune system within the tumour microenvironment. This role will focus on establishing cell-based and in vivo models and mechanism of action assays designed to validate potential immuno-oncology targets and test the efficacy of immunotherapy candidates. 

Key Requirements

We are looking for candidates who are passionate about drug discovery in cancer biology and immune-oncology. Demonstrable skills and first-hand experience with molecular cloning, characterization of immune cell subtypes from heterogeneous populations using multi-parameter flow cytometry, a solid understanding of immunology assays and methods, and willingness to carry out in vivo work are essential. 

Skills that are desirable but not essential include:
  • Experience with processing primary tissue and whole blood as well as immune cell isolation and purification 
  • Functional immune assays (e.g. ELISpot, antigen presentation assay or immune cell-mediated cytotoxicity assays)
  • Genomic analysis such as scRNAseq and Totalseq
  • Hands-on experience with in vivo models of tumour biology

Department/Directorate Information

The Centre for Cancer Drug Discovery (CCDD), within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The CCDD’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the scientific disciplines are in place to make this possible, including medicinal chemistry, biology, structural biology, assay scientists, drug metabolism and clinical specialists. This is an exciting and fast-moving research setup and offers the opportunity to work within a multi-disciplinary environment using state-of-the-art techniques and equipment.

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr Ling Li via Email on [email protected].

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

 

We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.

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