LocationLocation:
Sutton
DepartmentDepartment:
Cancer Therapeutics
Salary Details:Salary Details:
£37,050 - £45,732
Contract:Contract:
Fixed term
External Advertising End Date
10 Nov 2024

Key Information

 
Salary£37,050 – £45,732 per annum. Commencement on the salary range is subject to comparable skills and experience. Future progression is based on annual performance review.
 
Duration of ContractFixed Term for 2 years (in the first instance)
Hours per week: 35 hours per week (Full Time)
Location: On site, Sutton
Closing Date: 10 November 2024. 

Due to the high volumes of applications we receive, we reserve the right to close the advert before the published closing date once we have received a sufficient number of applications.  Therefore we advise that you to submit your application, as early as possible to avoid disappointment.

This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here.

Job Details

We are seeking to appoint a Higher Scientific Officer within the Centre for Protein Degradation to deliver biology aspects of the Centre's projectsThe postholder will be working in a multidisciplinary team on discovery and validation of novel molecular glue and PROTAC targets and E3 ligases for challenging oncology indications, contributing to our exploratory and drug discovery efforts.

Key Requirements

This position is suitable for a strong team player who is technically-minded and passionate about innovative solutions for cancer drug discovery. They should have a PhD in biology or biochemistry with solid background in cancer cell biology and hands-on experience with in vitro genetic manipulation techniques applicable for target validation and interrogation of cell signalling pathways. Experience in targeted protein degradation, biochemical and pharmacology assays would be an additional advantage.

Department Information

This position will be based in the ICR's  Centre for Protein Degradation - a part of the ICR Centre for Cancer Drug Discovery (CCDD) specialising in developing novel drug modalities that re-wire tumour cells' signaling by targeted degradation of key oncogenic drivers. Our experienced biologists work closely with medicinal chemists, biophysicists, computational scientists and oncology specialists on expanding the repertoire of novel degradable drug targets and E3 ligases (enzymes that mediate protein degradation), identifying drugs using innovative screening platforms and characterising their mechanisms of action. Our research provides a nucleus for other teams internally and externally to explore the therapeutic potential of targeted protein degradation medicines. Together with the ICR academics, ICR CCDD and collaborations with pharmaceutical industry we develop these rapidly from the laboratory hypothesis-testing  to early clinical trials, for the benefit of cancer patients.

We encourage all applicants to look at the attached job pack for more detailed information about this role. For an informal discussion about the role please feel free to contact Dr Agnieszka Konopacka, Group Leader, Induced Proximity Therapeutics, via email: [email protected].

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.

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