Higher Scientific Officer, Target and E3 Ligase Discovery, Biology - Centre for Protein Degradation

We are seeking to appoint a Higher Scientific Officer within the Centre for Protein Degradation to deliver biology aspects of the Centre's projects. The postholder will be working in a multidisciplinary team on discovery and validation of novel molecular glue and PROTAC targets and E3 ligases for challenging oncology indications, contributing to our exploratory and drug discovery efforts.

Key Requirements

Department Information

This position will be based in the ICR's  Centre for Protein Degradation - a part of the ICR Centre for Cancer Drug Discovery (CCDD) specialising in developing novel drug modalities that re-wire tumour cells' signaling by targeted degradation of key oncogenic drivers. Our experienced biologists work closely with medicinal chemists, biophysicists, computational scientists and oncology specialists on expanding the repertoire of novel degradable drug targets and E3 ligases (enzymes that mediate protein degradation), identifying drugs using innovative screening platforms and characterising their mechanisms of action. Our research provides a nucleus for other teams internally and externally to explore the therapeutic potential of targeted protein degradation medicines. Together with the ICR academics, ICR CCDD and collaborations with pharmaceutical industry we develop these rapidly from the laboratory hypothesis-testing  to early clinical trials, for the benefit of cancer patients.

We encourage all applicants to look at the attached job pack for more detailed information about this role. For an informal discussion about the role please feel free to contact Dr Agnieszka Konopacka, Group Leader, Induced Proximity Therapeutics, via email: [email protected].

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

We look forward to receiving applications from all candidates, wherever in the world they are currently based. We will select those who display the potential to become, or to support, the world leading cancer researchers of the future based on their application and performance at interview. However, we particularly welcome British applicants from black and ethnic minority backgrounds, as they are under-represented within the ICR and nationwide in STEM roles.