Postdoctoral Training Fellow - Chemistry, Targeted Protein Degradation

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Location:

Sutton

Department:

Cancer Therapeutics

Salary Details:

£41,607 to £48,224

Contract:

Fixed term

Contract Length:

Not Specified

Advertising End Date:

05 Jan 2025

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Postdoctoral Training Fellow - Chemistry, Targeted Protein Degradation

Key Information

Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performance review. If the candidate has completed their viva but has not yet been awarded their PhD, the starting salary will be £35,844, pre-PhD level. Progression to the full PDTF scale will commence once confirmation of PhD award is received. Award must be provided within 6 months of start date.

This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here.

Duration of Contract: Fixed Term for 3 years (in the first instance)

Hours per week: 35 hours per week (Full Time)

Closing Date: 05 January 2025

Location: Sutton (working onsite)

Job Details

We are seeking to appoint a Postdoctoral Training Fellow within the Targeted Protein Degradation team to support projects and drug discovery efforts within the ICR's Centre for Protein Degradation.

Working as part of a multidisciplinary team, the post-holder will use in-house biological and pharmacokinetic data and structural information to design new molecules and develop and execute synthetic routes. The candidate will develop their existing skills in organic chemistry, and learn or enhance their knowledge and experience in applied medicinal chemistry and chemical biology. The candidate will also be trained to use biochemical and cell-based assays to test the project compounds.

For general information on Post Doc's at The ICR can be found here.

Key Requirements

The successful candidate must have a PhD in organic chemistry, medicinal chemistry or a closely related discipline and have demonstrated experience of laboratory organic synthesis. They should have enthusiasm to work in a lab-based role in a multidisciplinary environment with the goal of discovering improved cancer therapeutics, and be motivated to develop their skills in medicinal chemistry.

The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as a PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years

Department/Directorate Information:

The CPD's mission is to advance and deploy Targeted Protein Degradation (TPD) approaches to study cancer biology and develop breakthrough cancer treatments. The CPD programmes span across three main research themes: PROteolysis Targeting Chimeras (PROTACs), Molecular Glue Degraders (MGDs), and Enabling novel E3 ubiquitin ligases. The highly collaborative Centre is linked with the Centre for Cancer Drug Discovery (CCDD) and is designed to leverage broad expertise and capabilities at the ICR and our hospital partner, The Royal Marsden, to develop protein degraders from initial concept to clinic, both within and beyond the ICR.

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Prof. Zoran Rankovic via email: [email protected].

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.

Don't let a checklist of qualifications hold you back – if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.

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