Postdoctoral Training Fellow - Epigenetic mechanisms of immunotherapy resistance (Dr Natrajan)

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Location:

Chelsea

Department:

Functional Genomics

Salary Details:

Salary Range: £35,844 - £48,224 per annum

Contract:

Fixed term

Contract Length:

Not Specified

Advertising End Date:

27 Nov 2024

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Postdoctoral Training Fellow - Epigenetic mechanisms of immunotherapy resistance (Dr Natrajan)

Key Information

Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performance review. If the candidate has completed their viva but has not yet been awarded their PhD, the starting salary will be £35,844, pre-PhD level. Progression to the full PDTF scale will commence once confirmation of PhD award is received. Award must be provided within 6 months of start date.

This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here.

Duration of Contract: 3 years

Hours per week: 35 hours per week

Closing Date: Wednesday 27 November

Job Details

Under the leadership of Dr Rachael Natrajan, we are seeking to appoint a Postdoctoral Training Fellow to join our Functional Genomics team.

Triple negative breast cancer (TNBC) is an aggressive form of breast cancer characterised by high levels of molecular heterogeneity that underpin its high recurrence rate after neoadjuvant immunotherapy and chemotherapy. There is an unmet clinical need to identify the molecular events that underpin this process and how they evolve over time. Moreover, identifying biomarkers that will aid in predicting which patients will relapse are much needed.

We are seeking a highly motivated Post Doctoral Training Fellow for a collaborative project supervised by Dr. Rachael Natrajan and co-mentored by Dr. Esther Arwert, to lead on the biological and mechanistic insights into the evolutionary dynamics of the epigenetic sub-clonal evolution of response to neoadjuvant immunotherapy and chemotherapy in TNBC in vivo mouse models using using high throughput cellular tracking coupled with single cell sequencing and functional genomic screening approaches. These will be linked to single cell epigenetic profiling from TNBC patient samples.

The candidate will perform experimental work to identify epigenetic regulators of neoadjuvant immunotherapy and chemotherapy resistance in TNBC and assess the implications of novel biology using innovative in vivo models and developing genetic screening approaches in vitro and in vivo.

The role will work collaboratively together with a dedicated computational biologist working on the analysis of the single cell and spatial data generated from the wider project goals. See Job reference: Analytical Scientist in single cell & spatial genomics (ID: 1068)

Key Requirements

You should possess a PhD in biology, biochemistry, genetics or other associated subjects and have an excellent track record in biomedical research and experience in cell and molecular biology. Experience with in vitro and in vivo cancer models is essential.

The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years

For general information on Post Doc's at The ICR can be found here.

Department/Directorate Information:

The Functional Genomics laboratory headed by Dr. Rachael Natrajan is a multidisciplinary dynamic research group with the mission to develop new treatment strategies for breast cancers resistant to standard of care therapies. We have made novel advances into the understanding of genomic alterations both at bulk and single cell level and their impact on breast cancer in different contexts and how to target these effectively.

The Functional Tumour Immunology laboratory, led by Dr. Esther Arwert, focusses on uncovering tumour microenvironmental mechanisms that drive immune escape and therapy resistance, using cutting-edge technology and sophisticated mouse models, to investigate how the tumour microenvironment modulates antigen-specific T cell responses.

As part of the ICR's Centre for Cancer Evolution and Translational Immunotherapy Initiatives, we collaborate across disciplines to understand the evolutionary mechanisms of therapy resistance and accelerate the development of more effective, targeted therapies for breast cancer.

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact [email protected]

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.

Don't let a checklist of qualifications hold you back – if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.

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