Under the leadership of Dr Joanna Loizou, we are seeking to appoint a Higher Scientific Officer to join the Target Validation and Genome Stability group within the Centre for Target Validation to carry out lab-based cell biology research focused on potential therapeutic targets in cancer.
Key Requirements
The successful candidate must have:
- At least a Masters level qualification in Cell Biology or an aligned subject (PhD in Cell Biology or an aligned subject is desirable)
- Knowledge of cancer biology
- Knowledge of experimental approaches to therapeutic target validation in cancer
- Skills in cell biology techniques used for target validation
- Expertise in a range of biology readouts used for screening and biomarker detection
- Experience working in lab-based cell biology (can include PhD)
Department/Directorate Information
The Target Validation and Genome Stability Group, led by Dr Joanna Loizou, focuses on identifying vulnerabilities in the DNA damage response to generate pre-clinical information that can lead to the identification of novel targets for drug discovery programmes.
The ICR has established a Centre for Target Validation that will accelerate the translation of ICR and collaborator research into drug discovery programmes. The Centre will deliver bespoke, hypothesis-driven data packages to support decision-making for launch of drug discovery projects. The Centre’s dedicated resources, including biology, functional genomics, assay sciences, chemistry, and bioinformatics teams, will support joint project teams that combine the deep biological and therapeutic knowledge of ICR investigators with the validation and technical expertise of drug discovery scientists. Scientists in the Centre for Target Validation will work closely with colleagues in the ICR’s Centre for Protein Degradation to exploit emerging technology and protein degradation tools for robust target validation experiments. The Centre for Target Validation will serve as a hub, connecting researchers to expertise and resources that will validate and streamline robust, targets into drug discovery programmes in the ICR’s Centre for Cancer Drug Discovery or into collaborative programmes with external commercial therapy discovery partners.
We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr Joanna Loizou via Email on [email protected].