Postdoctoral Training Fellow: In Situ Structural Biology

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Location:

Chelsea

Department:

Structural Biology

Salary Details:

Salary Range: £45,600 - £49,350 per annum

Contract:

Fixed term

Contract Length:

Not Specified

Advertising End Date:

09 Mar 2025

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Postdoctoral Training Fellow: In Situ Structural Biology

Key Information

Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performance review.

This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here.

Duration of Contract: Fixed Term for 3 years initially

Hours per week: 35 hours per week (full time)

Location: Chelsea

Closing Date: Sunday 9th March

Please note applications will be viewed on receipt; we reserve the right to close the role early.

Job Details

Under the leadership of Professor Sebastian Guettler, we seek a Postdoctoral Training Fellow to join the Structural Biology of Cell Signalling Group at ICR's Chester Beatty Laboratories, Fulham Road in London. The new Team Member will investigate the structure of macromolecular assemblies in situ, using cryogenic fluorescence microscopy and cryo-electron tomography (cryo-ET), with a particular emphasis on the mechanisms of the ADP-ribosyltransferase tankyrase. The Team Member will be supported by ICR's Light and Electron Microscopy Facilities and benefit from recent investments into in situ structural biology at the ICR.

General information on Postdocs at the ICR can be found here.

Key requirements

The successful candidate must have a PhD in a biological science or any other area relevant to the laboratory's research. Experience in cryo-EM is essential, and experience in in situ structural biology approaches is desirable.

The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 6 years as a PTDF at the ICR (this includes experience gained at PDTF level prior to joining the ICR)

Department/Directorate Information

The candidate will work in the Structural Biology of Cell Signalling Group within the ICR Division of Structural Biology headed by Professor Laurence Pearl and Professor Sebastian Guettler. The Division features state-of-the-art structural biology infrastructure and a vibrant research community. Its Electron Microscopy Facility is equipped with a 200-keV Thermo Fisher Scientific Glacios TEM with a Falcon 4i detector. The ICR further has access to Krios microscopes via the Electron Bio-Imaging Centre (eBIC) at the Diamond Light Source and the London Consortium for Cryo-EM (LonCEM). Recent investments include equipment for in situ structural biology, particularly a Leica EM GP2 plunge freezer, an EM ICE high-pressure freezer, an Ultracut ultramicrotome with an FC7 cryo-chamber, a STELLARIS 5 cryo-confocal microscope, and a Thermo Fisher Scientific Selectris energy filter for ICRs Glacios TEM. FIB-SEM access is available through eBIC. An initiative to establish FIB-SEM at the ICR is underway.

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Sebastian Guettler via email on [email protected].

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.

Don't let a checklist of qualifications hold you back – if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.

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