LocationLocation:
Sutton
DepartmentDepartment:
Cancer Therapeutics
Salary Details:Salary Details:
£39,805 - £49,023
Contract:Contract:
Fixed term
External Advertising End Date
03 Apr 2025

Key Information

Salary: £39,805 - £49,023 per annum. Commencement on the salary range is subject to comparable skills and experience. Future progression is based on annual performance review.
Reporting to: Dr Agnieszka Konopacka
Duration of ContractFixed Term for 2 years (in the first instance)
Hours per week: 35 hours per week (Full Time)
Location: Sutton (on site)
Closing Date: 03 April 2025
 

We will be reviewing the applications on an ongoing basis. Therefore, we advise you to submit your application without delay.


Job Details

We are seeking to recruit a Higher Scientific Officer within the Induced Proximity Therapeutics (IPT) Team in the ICR Centre for Protein Degradation to support our molecular glue and PROTAC drug discovery projects and expand induced proximity technology. The IPT team focuses on three main areas of research:
  • Cancer target validation
  • Screening, profiling and molecular mechanism of action of molecular glue and PROTAC degraders
  • Novel E3 ligase biology and ligand discovery
The successful candidate will work in a multidisciplinary team and play a key role in target validation, developing in vitro and cell-based assays, and pharmacological characterisation of novel molecular glue degraders and PROTACs, but may also contribute to other activities.
 
 About you
 
 The successful candidate:
  •  Will be a strong team player who is technically minded and passionate about science and cancer drug discovery
  •  Will hold a first degree, and preferably a PhD, in biological science or biochemistry
  •  Will have experience in cancer biology/target validation, genetic manipulation techniques, in vitro and cell-based assay development and pharmacological compound profiling
 Experience in targeted protein degradation will be a significant advantage.
 
Department/Directorate Information
 
This position will be based in the ICR's Centre for Protein Degradation, a part of the Centre for Cancer Drug Discovery (CCDD) specialising in developing novel drug modalities that re-wire tumour cells' signalling by targeted degradation of key oncogenic drivers. Our experienced biologists work closely with medicinal chemists, biophysicists, computational scientists, oncology specialists and physicians on discovering new medicines - molecular glue degraders and PROTACs - using innovative screening platforms and characterising their mechanisms of action, as well as expanding the repertoire of novel degradable drug targets and E3 ligases (enzymes that mediate protein degradation). Our research provides a nucleus for the academics and pharmaceutical industry to explore therapeutic potential of targeted protein degradation from laboratory hypothesis-testing to early clinical trials, for the benefit of cancer patients.
 
 What we offer
  •  A dynamic and supportive research environment in one of the successful academic cancer drug discovery centres in the UK
  •  Access to state-of-the-art facilities and professional development
  •  Collaboration with leading drug discovery and oncology scientist
  •  Competitive salary and pension

To learn more about this role, please download the attached job pack. For informal inquiries, please contact Dr Agnieszka Konopacka, Group Leader, Induced Proximity Therapeutics, Centre for Protein Degradation via email: [email protected].


About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.

Don't let a checklist of qualifications hold you back – if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.

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