We are looking for an enthusiastic and motivated clinical academic researcher to establish an independent research programme in Children and Young People’s Brain Tumour Research. In addition, the post-holder will have a 50% clinical post with Great Ormond Street Hospital (GOSH) as detailed in the clinical job plan, and will be expected to develop meaningful collaborations, and to help build molecular pathology research capacity across both institutions. It is intended that the new appointee will support the GOSH neuropathology service and will be expected to contribute to the surgical pathology and post-mortem responsibilities alongside the other Consultant Neuropathologists at GOSH.
The appointment will be clinician scientist level with an associated honorary consultant appointment at GOSH. This post is a full-time joint academic and NHS consultant post (10 PAs incl. 2 SPAs). The appointee will split their time between academic work at the Institute of Cancer Research (5PAs) and diagnostic neuropathology work at Great Ormond Street Hospital (5PAs).
About you
We aim to recruit an academic neuropathologist with extensive molecular biology research and clinical diagnostic experience to bring cutting-edge molecular analyses to bear to the most pressing questions in children and young people’s brain tumour classification and biology.
The aim of such research could include, but not be restricted to, the refinement of recognised diagnostic classification though the application of novel analytical techniques and/or computational methods, the mechanistic understanding of distinct biological drivers of novel brain tumour subgroups, and the use of single cell developmental atlases to identity the lineages of origin of distinct molecularly-defined subtypes. There should be a strong integration of morphological, clinical and molecular analyses.
You will have clinical and research expertise in paediatric neuropathology as demonstrated by specialist clinical experience and publication.
Department/Directorate Information
ICR: Through our Centre for Children and Young People’s Cancer (CCC) we are keen to develop outstanding researchers in this area. In particular, we are keen to expand our research in CNS tumours in this age group, taking advantage of both the existing expertise, and also the considerable opportunities afforded by recent advances in the biological characterisation of these tumours, linked to integration of molecular profiling techniques into classification and routine diagnostics.
Brain tumours in children and young people represent a remarkably diverse set of tumours, marked by a plethora of distinct biological and clinical subgroups within pathological entities, and with a wide range of lineages of origin despite often similar histological presentations. Whilst we have an increased understanding of many such tumour types, there remains a large unmet need to further refine classification schema, particularly for rare entities, and to translate the identification of pathognomic driver alterations into novel diagnostic tests and/or therapies.
The Division of Cancer Biology is focused on understanding the molecular alterations important in the development and progression of cancer, and in determining how the disease responds to treatment. The goal is to translate advances in the molecular characterisation of tumours into approaches to successfully implement personalised cancer treatment.
The Division of Cancer Biology was previously known as the Division of Molecular Pathology. The division's name was changed in February 2025 to better reflect the science happening within it.
GOSH: It is intended that the new appointee will support the neuropathology service and will be expected to contribute to the surgical pathology and post-mortem responsibilities alongside the other Consultant Neuropathologists at GOSH.
What we offer
- A dynamic and supportive research environment
- Access to state-of-the-art facilities and professional development opportunities
- Collaboration with leading researchers in the field
- Competitive salary and pension
We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Chris Jones [email protected]