Postdoctoral Training Fellow in RNA and Leukaemia Biology

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Location:

Sutton

Position:

Cancer Biology

Salary Details:

From £45,600 per annum

Contract:

Fixed term

Contract Length:

Not Specified

Advertising End Date:

02 Mar 2026

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Postdoctoral Training Fellow in RNA and Leukaemia Biology

Key Information

Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performance review.

Duration of Contract: Fixed Term for 3 years

Hours per week: 35 hours per week

Location: Sutton

Closing Date: 2nd March 2026

This role is eligible for ICR Sponsorship. If this is your first visa in the UK, support will be provided for costs associated with Visa application. If you are considering relocating to the UK, further information can be found here.

Job Details

Under the guidance of Professor Kamil Kranc, we are seeking to recruit a Postdoctoral Training Fellow to work on therapeutic targeting of RNA modifications in acute myeloid leukaemia (AML). The successful candidate will investigate strategies to eliminate leukaemic stem cells and play a central role in developing curative treatments for this aggressive disease.

Our recent work has demonstrated that inactivation of readers of the m⁶A mRNA modification represents a promising, non-toxic strategy for targeting leukaemic stem cells in AML (Paris et al., Cell Stem Cell, 2019; Mapperley et al., Journal of Experimental Medicine, 2021; Turner et al., eLife, 2022). Building on these findings, the postholder will explore the impact of disrupting the YTHDF family of m⁶A readers on AML biology, identify disease subtypes most responsive to this approach, test novel small-molecule inhibitors in vivo, and uncover synthetic lethal interactions and resistance mechanisms to guide rational combination therapies.

About you

The successful candidate must have:

PhD in biochemistry, RNA biology, cell biology, molecular biology, stem cell biology, oncology or similar.
Excellent verbal and written communication skills. Essential for communicating research, training others and drafting of reports or publications.
Significant experience in RNA biology, stem cell biology, and cancer research.
An excellent publication record with a track record of research excellence.

Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment.

The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years.

For general information on Postdocs at The ICR, more information can be found here.

Department/Directorate Information

The Haemato-Oncology Group specialises in understanding and targeting leukaemic stem cells, which are responsible for AML initiation, disease progression, relapse, and resistance to conventional therapies. Our group focuses on discovering cures for acute myeloid leukaemia with an aim to identify novel therapeutic targets for selective elimination of LSCs, without disrupting normal haematopoiesis.

What we offer

A dynamic and supportive research environment
Access to state-of-the-art facilities and professional development opportunities
Collaboration with leading researchers in the field
Competitive salary and pension

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Professor Kamil Kranc via email on [email protected]

About The Institute of Cancer Research

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.

Don't let a checklist of qualifications hold you back – if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.

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