Computational Chemist

The Centre for Protein Degradation (CPD), led by Professor Zoran Rankovic, is a recently established centre at the ICR dedicated to discovering and developing novel cancer treatments through targeted protein degradation. The Centre brings together expertise in medicinal chemistry, structural biology, cell biology and computational science to design PROTACs, molecular glue degraders, and novel E3 ubiquitin ligase chemical probes, with the aim of developing breakthrough treatments for the benefit of cancer patients.

Under the guidance of Dr Andrea Scarpino, we are looking to appoint a Computational Chemist to join the CPD and play a key role in applying and developing innovative computational chemistry methods to accelerate the design and discovery of novel protein degraders. The successful candidate will work in close collaboration with medicinal chemists, structural biologists and biologists within the Centre, contributing computational expertise across all stages of TPD drug discovery - from target evaluation and hit finding through to lead optimisation and candidate selection.

About you

The successful candidate must have a PhD in computational chemistry, cheminformatics or a related field, together with post-PhD experience applying computational chemistry methods for drug discovery. Familiarity with targeted protein degradation, including ternary complex and protein-protein interaction modelling, is highly desirable. 

What we offer

• A dynamic and supportive research environment
• Access to state-of-the-art facilities and professional development opportunities
• Collaboration with leading researchers in the field
• Competitive salary and pension

We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion on the role, please contact Dr Andrea Scarpino via email at [email protected]

Why work for us?

As a member of staff, you'll have exclusive access to a range of staff benefits.

The ICR is committed to supporting overseas applicants applying for roles, please click here to find out further information.

The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here.

At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work.

Don't let a checklist of qualifications hold you back – if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.