We seek a Higher Scientific Officer within the Centre for Target Validation to carry out lab-based cell biology research focused on potential therapeutic targets in cancer. Projects will involve the use of genetic techniques (RNAi/CRISPR), targeted protein degradation, tool compounds and molecular biology to generate key decision-making data in target validation and enable target prioritisation for drug discovery. The postholder will also contribute to assay development and biomarker discovery for targets that move to a drug discovery phase within the ICR’s Centre for Cancer Drug Discovery.
About you
The successful candidate must have:
- At least a Masters level qualification in Cell Biology or an aligned subject.
- Knowledge of cancer biology
- Knowledge of experimental approaches to therapeutic target validation in cancer
Please access the job pack attached for the detailed job description and person specification.
Department/Directorate Information
The ICR has established a Centre for Target Validation that will accelerate the translation of ICR and collaborator research into drug discovery programmes. The Centre will deliver bespoke, hypothesis-driven data packages to support decision-making for launch of drug discovery projects. The Centre’s dedicated resources, including biology, functional genomics, assay sciences, chemistry, and bioinformatics teams, will support joint project teams that combine the deep biological and therapeutic knowledge of ICR investigators with the validation and technical expertise of drug discovery scientists. Scientists in the Centre for Target Validation will work closely with colleagues in the ICR’s Centre for Protein Degradation to exploit emerging technology and protein degradation tools for robust target validation experiments. The Centre for Target Validation will serve as a hub, connecting researchers to expertise and resources that will validate and streamline robust, targets into drug discovery programmes in the ICR’s Centre for Cancer Drug Discovery or into collaborative programmes with external commercial therapy discovery partners.
What we offer
- A dynamic and supportive research environment
- Access to state-of-the-art facilities and professional development opportunities
- Collaboration with leading researchers in the field
- Competitive salary and pension
We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Joanna Loizou via Email on [email protected]