Under the leadership of the Director of the Centre for Protein Degradation, we are seeking to appoint a Staff Scientist or Senior Staff Scientist to lead the conception and delivery of biology components of Centre projects, including through their own research contributions. Projects will involve the coordination of research to evaluate new degradation approaches, establishing relevant assays for small molecule degraders, and applying chemical and biological targeted protein degradation technologies to new drug target validation. To support these aims, the post holder will supervise a small group of biology scientists dedicated to the Centre’s projects. The post holder will play a key role in establishing and supporting collaborative protein degradation projects across ICR, including coordinating proteomics experiments in collaboration with the ICR Functional Proteomics Group. The post holder will work closely with the computational biology team in the Centre for Cancer Drug Discovery to analyse biological datasets from profiled compounds and targeted degradation experiments, to prioritise new drug discovery targets.
Key Requirements
The successful candidate will have the skills and expertise to lead the biology aspects of collaborative multi-disciplinary research projects within the Centre for Protein Degradation.
Department Information
Scientists in the Centre for Cancer Drug Discovery implement innovative drug discovery technologies, discover novel mechanism-based drugs, and develop these as rapidly as possible from the laboratory through to hypothesis-testing early clinical trials. We publish our work extensively and have a large network of collaborations with academia, biotechnology companies, and the pharmaceutical industry. Our drug discovery Biology teams are dedicated to translational and drug discovery research, applying molecular pharmacology and cancer biology approaches to explore the therapeutic potential of new targets, and implementing functional and mechanistic assays to support progression of new small molecule therapeutics.
Based within the ICR Centre for Cancer Drug Discovery, the Centre for Protein Degradation's scientists apply a wide range of protein degradation technologies to benefit fundamental discovery science and translational research across the ICR. This research provides a nucleus for other teams to collaborate with, bringing their specialist biological and clinical knowledge to enable the exploration of therapeutic protein degradation for cancer patient benefit.