We are seeking to appoint a Data Scientist to join the Centre for Target Validation at the ICR. The postholder will use machine learning / AI and other bioinformatics approaches to identify/develop patient hypotheses, explore target/tumour links and discover biomarkers. Their work will contribute to target identification and validation, assist the clinical translation of our research and align with the ICR strategy to defeat cancer.
Key Requirements
The successful applicant will work on the application and development of machine learning/AI tools for the integration of multi-omics patient-derived data (e.g. RNA/DNA/Ribo-seq/proteomics) with patient survival outcomes, cell line model data (e.g. DepMap sensitivity and chemogenomics screens) and target ligandability potential (Chemistry and 3D structure assessments). The data integration via machine learning has the potential to generate novel patient hypotheses for drug discovery projects, not achievable from analysis of the component datasets.
Work experience in relevant research areas is required, preferably focused on cancer biology. Typically, candidates holding a PhD qualification and some work experience will be suitable for this role.
We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr Konstantinos Mitsopoulos via Email on [email protected].
Department/Directorate Information
Centre for Target Validation
The ICR has established a Centre for Target Validation that will accelerate the translation of ICR and collaborator research into drug discovery programmes. The Centre will deliver bespoke, hypothesis-driven data packages to support decision-making for launch of a drug discovery project. The Centre’s dedicated resources, including biology, functional genomics, assay sciences, chemistry, and bioinformatics teams, will support joint project teams that combine the deep biological and therapeutic knowledge of ICR investigators with the validation and technical expertise of drug discovery scientists. Scientists in the Centre for Target Validation will work closely with colleagues in the ICR’s Centre for Protein Degradation to exploit emerging technology and protein degradation tools for robust target validation experiments. The Centre for Target Validation will serve as a hub, connecting researchers to expertise and resources that will validate and streamline robust, targets into drug discovery programmes in the ICR’s Cancer Therapeutics Unit or into collaborative programmes with external commercial therapy discovery partners.
Centre for Cancer Drug Discovery
The Centre for Cancer Drug Discovery (CCDD), within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The CCDD’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the scientific disciplines are in place to make this possible, including medicinal chemistry, biology, structural biology, assay scientists, drug metabolism and clinical specialists. This is an exciting and fast-moving research setup and offers the opportunity to work within a multi-disciplinary environment using state-of-the-art techniques and equipment.